The spontaneous chuckle erupting out of you requires creativity, attuned observation skills and precise timing on the behalf of the comedian. To make someone laugh, as another comedian puts it, “is a preposterous thing. I am forcing you to have an involuntary reaction to something I say.” Professional comedians (like Louis C.K.) are experts at combining these skills and generating humorous ideas for our enjoyment, and indeed – making us laugh. How is a joke set in motion within the brain networks of a professional humor maker?